Juvenile nasopharyngeal angiofibroma is a pathologically benign yet locally aggressive and destructive vascular lesion of head and neck. The juvenile nasopharyngeal angiofibroma (JNA) is a highly Nasoangiofibroma youth is a highly vascularized tumor almost exclusively male. Juvenile nasopharyngeal angiofibromas (JNA) are a rare benign but locally aggressive vascular tumor. Epidemiology Juvenile nasopharyngeal angiofibromas.

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JNA classically presents as a painless, progressive unilateral nasal obstruction. A case report of JNA with rare intra-oral manifestation in a year-old male patient is presented in the article.

Immunohistochemical and electron microscopical characterization of stromal cells in nasopharyngeal angiofibromas. Preoperatively, all the three patients were embolized and this step seems to be helpful for endoscopic approach to prevent intraoperative hemorrhage. The presence of prominent flow voids lead to a salt and pepper appearance on most sequences and nasofarjng characteristic 5,6.

If nasopharyngeal angiofibroma is suspected based on physical examination a smooth vascular submucosal mass in the posterior nasal cavity of an adolescent maleimaging studies such as CT or MRI should be performed. The propensity of the lesion to cause life threatening complications by way of massive bleeding has led to acquisition of considerable importance in otolaryngology practice.


Juvenile nasopharyngeal angiofibroma JNA is a benign neoplasm of the nasopharynx. Diagnosis of JNA is made by complete history, clinical examination, radiography, nasal endoscopy and by using specialized imaging techniques such as arteriography, computer tomography and magnetic resonance imaging. Ear Nose Throat J. Diagnostic and therapeutic management. DSA digital subtraction angiography of carotid artery to see the extension of tumors and feeding vessels.

Mortality is not associated with nasopharyngeal angiofibroma.

Angiography, although not essential, is often useful in both defining the feeding vessels as well as in preoperative embolisation.

This approach obviates the need for any skin incision and hence no cosmetic defect is expected. The patients were advised to undergo preoperative arterial embolization prior to surgery. The patients were treated surgically using various surgical approaches like trans-palatal, endoscopic trans-nasal, lateral rhinotomy and trans-maxillary approach depending on their JNA stage. Juvenile nasopharyngeal angiofibroma or nasopharyngeal angiofibroma is an uncommon disease of male adolescents.

Nasopharyngeal angiofibroma – Wikipedia

Antral sign or Holman-Miller sign forward bowing of posterior wall of maxilla is pathognomic of angiofibroma. Case 1 Case 1. Histopathologically JNA shows a fibrocellular stroma with spindle cells and haphazardly arranged collagen interspersed with an irregular vascular pattern.

It most commonly affects adolescent males and may grow into fissures of the skull and may spread to adjacent structures. Published online Jan Loading Stack – 0 images remaining. Diagnosis is arrived at by clinical examination, radiography, nasal endoscopy and specialized beila techniques such as CT scan and MRI.


Nasopharyngeal angiofibroma

On examination, it may be seen as a pale reddish-blue mass. Six out of thirteen patients case nos. Arteriography followed by preoperative embolization and surgical resection is the treatment of choice.

Type I includes lesions fundamentally localized to the nasal cavity, paranasal sinus, nasopharynx, or pterygopalatine fossa. The disadvantages are it is technically difficult in untrained hands and visibility drastically reduces if endoscope comes in contact with blood. Diagnosis of JNA is made by complete history, clinical examination, radiography, nasal endoscopy; and specialized imaging techniques such as arteriography, CT, and magnetic resonance imaging MRI.

A higher density toward the periphery is noted, which was seen in the present case too. It was due to mass in nasopharynx obstructing choana. The prevalence in males may be explained by high androgen receptor AR expression suggesting that JNA is androgen dependent.

This makes it possible to precisely stage JNA. Imaging in the diagnosis of juvenile nasopharyngeal angiofibroma.